HONG-WEI DONG, Ph.D.

CURRICULUM VITAE

Update 1/1/2012

Title: Research Assistant Professor
 

Address:

Department of Anatomy and Neurobiology
University of Tennessee Health Science Center
855 Monroe Ave., Suite 515
Memphis, TN 38163
Tel. (901) 448-2771
Fax: (901) 448-7193
Email: hdong5@uthsc.edu

 

 

Education:

 

2003  Certificate in Information Technology, Department of Computer of Science, Webster University. St. Louis. USA

 

1997   Ph D., Neurobiology, Neuroscience Research Institute, Peking University, Health Science Center, China. Supervisor: Dr. Ji-Sheng Han

 

1992   MD, Clinical Medicine, Hebei Zhang Jia Kou Medical College, China.

                                      

Professional Experience:

 

2005- Present, Assistant Professor, Department of Anatomy and Neurobiology, University of Tennessee, Health Science Center. Major: Neurobiology.

 

2004 -------- 2005, Research Scientist, Department of Anatomy and Neurobiology, University of California in Los Angeles, David Geffen School of Medicine.

Major: Psychology and Neurobiology.

 

1999 -------- 2003, Research Associate, Department of Anatomy and Neurobiology, Washington University in St Louis, School of Medicine,

Major: Neurobiology

 

1997 -------- 1998, Postdoctoral Fellow, Department of Physiology and Pharmacology, School of Medicine, St Louis University.

Major: physiology and pharmacology.

 

1990 -------- 1992, Internship, rotated in all clinical departments in First Affiliate Hospital of Zhang Jia Kou, College of Medicine.

 

Research Interests:

 

1) The mechanisms of long lasting memory evoked by one-trail stimulation in the olfactory system by which a simulated sensor can be developed in environmental protection

2) Distribution of transient receptor potential channels (TRPs) in the brain and their roles played in the signaling transduction, especially in pain, olfaction and emotion.

3) The relationships between olfaction and pain, emotion and endocrine functions. 

4) The application of stem cells of olfactory system in the neurologic damage or neural degenerate diseases.

5Developing and testing possible pharmaceutical agents in treating chronic pain, ethanol or cocaine addiction.

 

Awards:

 

1) " Activity-dependent plasticity of sensory synapses in the olfactory bulb", R03DC009049, NIDCD, Principle Investigator, July 2007—Jun 2011, $150,000.

2) "Long-term plasticity of inhibitory synapses in the main olfactory bulb", 3R03DC009049-03S1, NIDCD, Principle Investigator, Aug 2009----July 2010, $25,000.

3) “Expression of Transient Receptor Potential Channels in Main Olfactory Bulb”, William Webster Endowment Fund Award, $10,000. 2010-2011.

4) "Metabotropic glutamate receptors in the main olfactory bulb. 5R01DC003195, NIDCD, Co-investigator, Jan 2007--Dec 2011, $1,125,000.

 

Teaching:

 

  1. Lectures, in physiology. Nursing School in my hometown. 1989,1990.
  2. Physiology lab, Medical student, Beijing University. 1992-1994.
  3. Neurophysiology lab. Graduate student, Washington University in St Louis, University of Tennessee, HSC. 1998-2003,2005-present.
  4. Lectures, Functional Neuroanatomy. Graduate student, University of Tennessee, HSC.
  5. Neuroanatomy Lab, Dental, Medical, Graduated and Public Allied Health students.

 

Publications (CA: Corresponding Author):

 

1.    Nai Q, Dong HW, Linster C. Ennis M. Activation of α1 and α2 noradrenergic receptors exert opposing effects on excitability of main olfactory bulb granule cells. Neurosci. 2010, 169:882-892.

2.    Dong HW, Heinbockel T, Hamilton KA, Hayar A, Ennis M. Metabotropic glutamate receptors and dendrodendritic synapses in the main olfactory bulb.  Annual New York Academy of Sciences 2009, 1170:224-238.

3.    Dong HW CA,  Hayar A, Callaway J, Yang XH, Nai Qiang, Ennis M. mGluR1 Activation enhances non selective cation currents and rhythmic bursting in external tufted cells. Journal of Neurosci. 2009, 38:11943-11953.

4.    Nai Q, Dong HW, Hayar A, Linster C, Ennis M. Regulation of GABAergic inhibition of mitral cells by noradrenergic system in rat main olfactory bulb. J Neurophysiol 2009, 101: 2472-2484.

5.    Dong HW CA, Hayar A. Ennis M. Activation of group I metabotropic glutamate receptors on main olfactory bulb granule cells and periglomerular cells enhances synaptic inhibition of mitral cells. J. Neurosci. 2007, 27:5654-5663.

6.    Dong HW, Buonomano DV. A technique for repeated recordings in cortical organotypic slices.  J. Neurosci. Method 2005, 146:69-75.

7.    Dong HW, Wang QX, Valkova K, Gonchar Y, Burkhalter A. Experience-dependent development of feedforward and feedback circuits between lower and higher areas of mouse visual cortex. Vision Res 44: 3389-3400. 2004

8.    Dong HW, Shao ZW, Nerbonne JM, Burkhalter A.  Frequency-dependent balance of synaptic excitation and inhibition in interareal feed-forward and feedback circuits of mouse visual cortex.  J Comp Neurol. 2004, 475:361-73.

9.    Dong HW CA, Wang LH, Zhang M, Han JS. Decreased Dynorphin A (1-17) in the spinal cord of spastic rats after the compressive injury. Brain Res. Bull. 2005, 67:189-195.

10. Zhang M, Wang XM, Zhang DB, Xu GH, Dong HW, Yu YX, Han JS. Orphanin FQ antagonizes the inhibition of Ca2+ currents induced by m-opioid receptors. J. Mol. Neurosci. 2005, 25:21-27.

11. Dong HW, Gan Q, Knuepfer MM.  Central CRF and adrenergic receptors mediate cocaine-induced hemodynamic response in rats.  Brain Res  2001,893:1-10.

12. Tang NM, Dong HW, Wang XM, Tsui ZC, Han JS.  Cholecystokinin antisense RNA increases the analgesic effect induced by electroacupuncture or low dose morphine: conversion of low responder rats into high responders.  Pain  1997,71:71-80.

13. Dong HW, Zhang W, Shi YS, Roques BP, Han JS.  The potentiation effect of RB101, enkephalin-degradation-enzyme inhibitor, on low frequency electroacupuncture analgesia.  Journal of Chinese Pain  1996,2:33-37.

14. Tang NM, Dong HW, Zhang LX, Han JS.  L365, 260, CCK-B receptor antagonist converse low responder rats to electroacupuncture into high responders.  Journal of Chinese Pain 1996,2:103-106.

15. Dong HW CA, Davis JC, Ding SY, Nai, Q, Zhou FM, Ennis M. Expression of Transient Receptor Potential (TRP) Channel mRNA in the Mouse Olfactory Bulb. Submitted to Chemical Sense.

16. Dong HW CA , Nai Q, Ennis M, Theta Burst Stimulation (TBS) of Olfactory Nerve (ON) evoked long term synaptic plasticity in glomerular layer (GL) of rat main olfactory bulb (MOB). In preparation.

 

Conference Presentation and Abstracts:

 

  1. Nai Q, Dong HW, Linster C, Ennis M. Activation of belta noradrenergic receptors enhances rhythmic activity in the main olfactory bulb. AchemS 32th Annual Meeting 2011, #P209
  2. Dong HW, Nai Q, Davis JC, Ennis M. Activation of metabotropic glutamate receptors (mGluRs) enhances persistent sodium currents in external tufted cells (ETCs). AchemS 32th Annual Meeting 2011, # p182
  3. Zhang WL, Dong HW, Nai Q, Zhang YH, Ennis M. Role of Group I and II Metabotropic Glutamate Receptors in Mouse Main Olfactory Bulb External Tufted Cell Responses to Olfactory inputs. AchemS 31th Annual Meeting 2010, #60.
  4. Dong HW, Nai Q, Ennis M. Theta Burst Stimulation (TBS) of Olfactory Nerve (ON) evoked long term synaptic plasticity in glomerular layer (GL) of rat main olfactory bulb (MOB). Beijing International Meeting on Research in Taste and Smell. 2009 #15.
  5. Dong HW, Ding SY, Nai Q, Zhou FM, Zhang YH, Zhang WL, Ennis M. Detection of transient receptor potential Channel mRNA expression in the mouse main olfactory bulb. Society of Neuroscience Conference  2009, 555.16 online.
  6. Dong HW, Ding SY, Nai Q, Zhou FM, Ennis M. Expression of transient receptor potential (TRP) channels in the mouse main olfactory bulb (MOB). AchemS 30th Annual Meeting 2009, 214.
  7. Nai Q, Dong HW, Linster, Ennis M. 1 and 2 noradrenergic receptor exert opposing effects on the excitability of rat main olfactory bulb (MOB) granule cells. AchemS 30th Annual Meeting 2009, 223.
  8. Dong HW, Nai Q, Ennis M. Activity-dependent plasticity in the strength of olfactory nerve (ON) synapses in the rat main olfactory bulb (MOB). Society for Neuroscience Conference 2008. 363.8 online
  9. Nai Q, Dong HW, Linster C, Ennis M. Activation of a1 and a2 noradrenergic receptors differentially regulates excitability of granule cells in the main olfactory bulb. Society for Neuroscience Conference 2008. 363.22
  10. Nai Q, Dong HW, Hayar A, Linster C, Ennis M. Noradrenergic modulation of GABAergic inhibition of main olfactory bulb mitral cells.  XV International Symposium on Olfaction and Taste, 2008, 365,
  11. Dong HW, Hayar A, Ennis M. Activation of group I mGluRs enhances rhythmic bursting and nonselective cation current in olfactory bulb external tufted cells. Society for Neuroscience Conference 2007, 277 online. 
  12. Nai Q, Dong HW, Hayar A, Linster C, Ennis M. Activation of a1 and a2 noradrenergic receptors differentially regulates GABAergic inhibition of mitral cells in the main olfactory bulb. Society for Neuroscience Conference 2007, 504 online
  13. Dong HW, Hayar A, Ennis M. mGluR1 activation enhances nonselective cation currents and thythmic bursting in external tufted (ET) cells. AchemS 29th Annual Meeting 2007, 292
  14. Dong HW, Hayar A, Ennis M. Activation of metabotropic glutamate receptors (mGluRs) in the glomerular layer (GL) and granule cell layer (GCL) of the olfactory bulb enhances synaptic inhibition of mitral cells. AchemS 28th Annual Meeting 2006, 238.
  15. Dong HW, Hayar A, Ennis M. Activation of metabotropic glutamate receptors (mGluRs) enhances synaptic inhibition of olfactory bulb mitral cells (MCs) via actions on GABAergic interneurons in the glomerular layer (GL) and granule cell layer (GCL). Society for Neuroscience Conference 2006, 542.5 online.
  16. Dong HW,Buonomano DV. Transient blockade of NMDA receptors produces a long-term enhancement of inhibition and metaplasticity of LTP. Society for Neuroscience Abstracts. 2005
  17. Dong HW, Burkhalter A. Differential effects of sensory experience on inhibition in feedforward and feedback circuits between different areas of mouse visual cortex. 266.12, Society for Neruoscience, 2003. Online.
  18. Dong HW, Burkhalter A. Input-Specific spike threshold in fast-spiking interneurons connected to FF and FB pathways between different areas of mouse visual cortex. 159.1 Society for Neuroscience, 2002. Online.
  19. Dong HW, Lin M., Burkhalter A.  Experience-dependent modification of the balance of synaptic excitation and inhibition in interareal feedback circuit in developing mouse visual cortex. Soc. Neurosci. Abstr. 2001 27:1249.
  20. Dong HW, Huang JS, Tonegawa S, Burkhalter A. Regulation of inhibition in developing interareal forward and feedback circuits in visual cortex of BDNF overexpressing mice. Soc Neurosci. Abstr. 2000, 26:855.
  21. Dong HW, Shao ZW, Burkhalter A.  Different balance of excitation and inhibition in interareal forward and feedback pathways of mouse visual cortex.  Soc. Neurosci. Abstr. 1999 25:2191.
  22. Dong HW, Gan Q, Knuepfer MM.  Central CRF and symbol 98 \f "Symbol" \s 10b-adrenergic receptors mediate cocaine-induced cardiac output responses in rats.  FASEB J  1998,12:A66 (abstract).

 

Invited Talk:

1.  Modulation of endogenous opioid and anti-opioid peptide on the acupuncture analgesia. Harvard Medical School, Brigham and Women’s hospital. 2004.

2.  The balance of excitation and inhibition of the neurocircuits in cortical cortex. University of Tennessee, Health Science Center. 2005.

3.  Theta burst stimulation (TBS) of olfactory nerve (ON) evoked long term synaptic plasticity in glomerular layer (GL) of rat main olfactory bulb (MOB). Capital Medical University. 2008

4.  Theta burst stimulation (TBS) of olfactory nerve (ON) evoked long term synaptic plasticity in glomerular layer (GL) of rat main olfactory bulb (MOB). National Psychological Institute, 2008.

5.  Metabotropic glutamate receptor’s modulation on the dendrodendritic synapses in the main olfactory bulb. Shang Hai Fudan Medical College, 2011.

6.  Metabotropic glutamate receptor’s modulation on the dendrodendritic synapses in the main olfactory bulb. Nantong University, 2011.

7.  Metabotropic glutamate receptor’s modulation on the dendrodendritic synapses in the main olfactory bulb. BIT’s Second World Congress of Neurotalk 2011.

 

Computer and Biological Skills:

 

Computational languanges: C/C++, Matlab, SPSS, Igor, Neurolab.

Software: Skillful of using various imaging, data analysis and office tools. Photoshop7.0, illustrator CS4, Origin 8.1, Coredraw 12.0, Minianalysis, Clampfit 10.0 and Microsoft office 2007.

Biological Skills: Expertise in in vivo and in vitro electrophysiology. Familiar with the general lab techniques in molecular biology, immunohistochemistry 

 

Professional Affiliations:

 

Member, Society of Neuroscience since 1998.

Member, Association of Chemical Sense since 2005.

 


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