Download my CV as a Word document: AbdallahCV.doc
1987: Lebanese Baccalaureate
in Experimental Sciences. Collège des Frères (Tripoli,
Lebanon)
1987-91: Bachelor of Sciences (B.S.)
major Biology, American University of
Beirut, P.O. Box: 11-2036, Beirut, LEBANON.
1991-92: Maitrise de Physiologie
Animale at the University
Louis Pasteur, Strasbourg. Major courses: Physiology of Excitable
Cells, Function and Regulation of Physiological Systems, Cellular
and Molecular Pharmacology.
1992-93: DEA Neurobiologie
et Physiologie des Systèmes de Communication. (U.L.P.)
Strasbourg.
Training at the laboratory of Neurophysiology and Neurobiology of
Endocrine
Systems (URA CNRS 1446) of Prof. P. Feltz. Research supervised by Prof.
Ken
Marshall (Univ. d' Ottawa, Canada).
1993-96: Ph.D. in Neurosciences
supervised and directed by Prof. Paul Feltz,
University Louis Pasteur of Strasbourg.
Thesis title: GABAergic and
noradrenergic responses in silent and spontaneously active neurons of
the rat rostral ventrolateral medulla in vitro.
Committee: Prof. Alan North, Pascal
Bousquet, Jean Champagnat, Rémy Schlichter.
1997-1999: Research Associate
at the University of Virginia.
Director: Prof.
Patrice Guyenet (see also Neuronal
Mechanisms in Cardiovascular Regulation Conference in Vermont July
11-15, 1999)
1999-: Research Assistant Professor
at the University of Maryland, Baltimore.
2003-: Research Assistant Professor
at the University of Tennessee,
Memphis.
2006-: Associate Professor
at
the University of Arkansas for Medical
Sciences,
Little Rock.
LANGUAGES
Fluent English, French and Arabic (mother tongue).
| SKILLS AND INTERESTS
Neurophilosophy, Science fiction, Political analysis, Reading,
Chess.
Computer skills:
- Operating Systems: MS-DOS, Windows,
Macintosh.Troubleshoot PC hardware and software.
- Application programs: : Microsoft Office, Canvas, Corel
Draw, Photoshop, Adobe Acrobat, OriginLab, MatLab, pClamp,
MiniAnalysis, Neuroplex, SAP, ARIA.
- Languages: MS-Qbasic, Assembler,
Internet Web page design.
|
|
RESEARCH
AND EXPERTISE
1991: - Autoradiographic technique on rat brain slices.
1992: - Intracellular pH
measurement by microfluorimetry using the BCECF probe.
- Intracellular
recordings in the locus coeruleus and the mesencephalic 5 trigeminal
nucleus in rat brainstem slices, and in substancia nigra slice-
Intracellular dye labeling.
1993: Job experience for 3 months in a pharmaceutical
industry, position held: “Cadre de Laboratoire” at Sanofi Research,
Montpellier, France.
1994-6: - Intracellular recordings of neurons in the rostral
ventrolateral medulla.
- In
situ hybridization (GABA mRNA subunits).
1997-9: - Intracellular,
extracellular and field potential recordings in brainstem slices.
-
Patch-clamp technique: Whole-cell, outside-out, and single channel
recordings.
-
Analysis of the properties of evoked, spontaneous, and miniature
postsynaptic currents mediated by glutamate and GABA.
-
Recordings from bulbospinal neurons identified with retrograde tracing
of fluorescent dyes injected in the spinal cord.
-
Immunocytochemical staining for tyrosine hydroxylase.
2000-6: - Simultaneous
whole-cell recordings from pairs of neurons in olfactory bulb slices.
- Auto- and
cross-correlation analysis of spike trains and waveforms.
2007: - Calcium and
voltage-sensitive dye imaging, confocal microscopy.
- Ultraviolet light
laser uncaging of glutamate in brain slices.
- Laser Doppler
measurement of cerebral blood flow.
AFFILIATIONS
Société
des Neurosciences (France), member (1994-2002).
Society for Neuroscience (U.S.A.),
member since 1996.
American Physiological Society
(U.S.A.), member since 1998.
International
Society for Autonomic Neuroscience, member since (1998-2002).
Association for
Chemoreception Sciences (AChemS), member since 1999.
Graduate Faculty
of the University of Maryland Graduate School, member (2001-2003).
Washington-Baltimore Computational
Neuroscience Interest Group, member (2001-2003).
FUNDING
1. R03 DC006356 grant: funding period: 5/1/04 - 4/30/07,
$50,000/year for
3 years. Role: Principal Investigator, NIH/NIDCD, Title: Synchronous
bursting among juxtaglomerular neurons. (CRISP
Abstract).
2. R01 DC007123 grant (percentile 5.1%) funding period: 7/01/05 -
6/30/10, $200,000/year for 5 years. Role: Principal Investigator,
NIH/NIDCD, Title: External tufted cells coordinate olfactory bulb
activity. (CRISP
Abstract).
PUBLICATIONS
- Garcia-Rill E,
Heister DS, Ye
M, Charlesworth A, Hayar A (2007)
Electrical coupling: novel mechanism for sleep-wake control. Sleep
(in press).
- Hayar
A,
Ennis M (2007) Endogenous GABA and glutamate finely tune the
bursting
of olfactory bulb external tufted cell. J
Neurophysiol 98:1052-1056. (Abstract)
(PDF, 209
KB).
- Dong HW, Hayar A, Ennis M
(2007) Activation of metabotropic glutamate
receptors (mGluRs) enhances synaptic inhibition of olfactory bulb
mitral cells
(MCs) via actions on GABAergic interneurons in the glomerular layer
(GL) and
granule cell layer (GCL). J Neuroscience 27:5654-5663. (Abstract) (PDF, 3304
KB).
- Heister DS, Hayar A,
Charlesworth A, Yates C, Zhou
YH, Garcia-Rill E (2007) Evidence for electrical coupling in the
SubCoeruleus
(SubC) nucleus. J
Neurophysiol 97:3142-3147.
(Abstract)
(PDF,
222 KB).
- Karnup SV, Hayar
A, Shipley MT,
Kurnikova MG (2006) Spontaneous field potentials in the glomeruli of
the
olfactory bulb: the leading role of juxtaglomerular cells. Neuroscience
142:203-221. (Abstract) (PDF,
1454 KB).
- Ennis
M, Zhu M, Hayar A (2006) Olfactory Nerve-Evoked,
Metabotropic Glutamate Receptor-Mediated Synaptic Responses In Rat
Olfactory
Bulb Mitral Cells. J Neurophysiol,
in
press, (Abstract)
(PDF, 2547
KB).
- Hayar A, Bryant JL, Boughter JD, Heck DH (2005) A no-cost
solution
to measure licking behavior in electrophysiological or behavioral
setups
with standard analog-to-digital converters. J
Neurosci
Methods, in press, (Abstract)
(PDF,
300 KB).
- Hayar A, Shipley MT, and Ennis M (2005) Olfactory bulb
external
tufted cells are synchronized by multiple intraglomerular
mechanisms. J Neuroscience
25:8197-8208 (Abstract)
(PDF, 934 KB).
- Hamilton KA, Heinbockel T, Ennis M, Szabo G, Erdelyi F, Hayar
A (2005) Properties of external plexiform layer interneurons in
mouse olfactory bulb slices. Neuroscience 133:819-829 (Abstract)
(PDF,
544 KB).
- Hayar A, Karnup S, Ennis M, Shipley MT (2004) External
tufted cells coordinate intra-glomerular circuit activity. J Neuroscience 24:6676-6685 (Abstract)
(PDF, 989 KB).
- Hayar A, Karnup S, Shipley MT, Ennis M (2004) Olfactory
bulb glomeruli: external tufted cells intrinsically burst at theta
frequency and are entrained by patterned olfactory input. J Neuroscience 24:1190-1199
(Abstract)
(PDF, 526
KB).
- Aungst JL, Heyward PM., Puche AC, Karnup SV, Hayar A,
Szabo G, Shipley MT (2003) Center-surround inhibition among olfactory
bulb glomeruli. Nature 426:623-629
(Abstract)
(PDF,
798 KB).
- Guyenet PG, Stornetta RL, Schreihofer AM, Pelaez NM, Hayar A,
Aicher S, Llewellyn-Smith IJ (2002) Opioid signalling in the rat
rostral ventrolateral medulla. Clin Exp
Pharmacol Physiol 29:238-242. Review. (Abstract)
(PDF,
58 KB)
- Ennis M., Zhou F-M., Ciombor KJ, Aroniadou-Anderjaska V, Hayar
A, Borrelli E, Zimmer LA., Margolis F, Shipley
MT (2001) Dopamine D2 Receptor-Mediated Presynaptic Inhibition
of Olfactory Nerve Terminals. J Neurophysiol
86:2986-2997. (Abstract)
(Full
Article) (PDF,
195 KB)
- Hayar A, Heyward PM, Heinbockel T, Shipley MT, Ennis M
(2001) Direct excitation of mitral cells by activation of
alpha1-adrenergic receptors in rat olfactory bulb slices. J Neurophysiol 86:2173-2182 (Abstract)
(Full
Article) (PDF,
199 KB)
- Hayar A, Guyenet P (2000) Prototypical imidazoline-1
receptor ligand moxonidine activates alpha2-adrenoceptors in
bulbospinal neurons of the RVL. J Neurophysiol
83:766-776 (Abstract)
(Full
Article) (PDF, 256 KB)
- Hayar A, Guyenet P (1999) Alpha2-Adrenoceptor-mediated
presynaptic inhibition in bulbospinal neurons of rostral ventrolateral
medulla. Am J Physiol: Heart and Circulatory
Physiology 277:H1069-H1080 (Abstract)
(Full
Article) (PDF, 457 KB)
- Hayar A, Guyenet P (1998) Presynaptic and postsynaptic
effects of methionine-enkephalin on identified bulbospinal neurons of
the RVL. J Neurophysiol
80:2003-2014 (Abstract)
(Full
Article) (PDF, 319 KB)
- Hayar A, Poulter MO, Pelkey K, Feltz P, Marshall KC (1997)
Mesencephalic trigeminal neuron responses to gamma-aminobutyric acid. Brain Res 753:120-127 (Abstract)
(PDF,
678
KB)
- Hayar A, Feltz P, Piguet P (1997) Adrenergic responses in
silent and putative inhibitory pacemaker-like neurons of the rat
rostral ventrolateral medulla in vitro. Neuroscience
77:199-217 (Abstract)
(Full Article) (PDF, 722 KB).
- Jung M, Michaud JC, Steinberg R, Barnouin MC, Hayar A,
Barnouin MC, Mons G, Souilhac J, Emonds-Alt X, Soubrie P, Le Fur G
(1996) Electrophysiological, behavioural and biochemical evidence for
activation of brain noradrenergic systems following tachykinin NK3
receptor stimulation. Neuroscience
74:403-414 (Abstract)
(PDF,
356 KB).
- Hayar A, Piguet P, Feltz P (1996) GABA-induced responses
in different electrophysiologically identified neurons in the rat
rostro ventrolateral medulla. Brain Res
709:173-183 (Abstract)
(PDF, 1149 KB).
BOOK CHAPTERS
1.
Ennis M, Hamilton KA, Hayar A.
(2007) Neurochemistry of the main olfactory system, In: Handbook of
Neurochemistry and Molecular Neurobiology, 3rd Edition (Lajtha A,
Editor-in-Chief), Vol. 20, pp 137-204, Sensory Neurochemistry (Johnson
DA, Volume Editor), Heidelberg: Springer, (PDF,
987 KB) http://www.springerlink.com/content/h02724/front-matter.pdf
2. Ennis M, Hayar A.
Physiology of the Olfactory Bulb, in Handbook of the Senses: Olfaction.
Firestein S, Smith DV, eds. In press. (Proof, PDF 10 MB).
SEMINARS AND
SLIDE TALKS
1. Hayar A. (Seminar) GABAergic and
noradrenergic responses in the rat rostral ventrolateral medulla (RVL)
in vitro: Relevance to cardiovascular regulation and vasomotor
rhythmogenesis. (July 1, 1996) International School for Advanced
Studies (SISSA), 2-4, via Beirut,
Trieste, Italy.
2. Hayar A, Guyenet P. (Slide talk) Pre-and postsynaptic
inhibitory actions of methionine-enkephalin on identified bulbospinal
neurons of
the rat rostral ventrolateral medulla. (Experimental Biology Meeting,
San Francisco, April 1998).
3. Hayar A, Karnup S, Shipley MT, Ennis M. (Slide
talk) Synchronous bursting among juxtaglomerular neurons of the rat
main olfactory bulb (MOB) in vitro. (31st Annual Meeting of the Society
for Neuroscience, San Diego,
November 2001).
4. Hayar A. (Seminar) Pre- and
postsynaptic inhibitory actions of methionine-enkephalin and
norepinephrine on identified bulbospinal neurons of the rat rostral
ventrolateral medulla. (Univ.
of Wyoming, Laramie, June 2002).
5. Hayar A. (Seminar) Synchronous
bursting among juxtaglomerular neurons of the olfactory bulb is
mediated by synaptic and non-synaptic interactions. Developmental
Neural Plasticity Unit, NINDS (NIH, Bethesda,
June
2003).
6. Hayar A. Invited speaker for the “Satellite symposium to the
2004 Computational Neuroscience meeting (CNS*04)”
July 17, 2004, Baltimore.
7. Hayar A. (4 Seminars, faculty candidate) Synaptic
transmission and gap junctions synchronize the bursting activity of
olfactory bulb
neurons. October, 2004, 1- Univ. of Drexel, Philadelphia,
2- Univ. of Illinois, Rockford, 3-
Univ. of Texas, Galveston, 4-
Univ. of North Dakota, Fargo.
MEETING
ABSTRACTS AND POSTERS
1. Marshall K, Hayar A, Feltz P. Responses
of mesencephalic trigeminal neurons to g-aminobutyric acid. Can. J.
Physiol. Pharmacol. Vol.72 (1994).
2. Hayar A, Poulter MO, Feltz P. g-Aminobutyric acid
responses in different electrophysiologically characterized neurons
within the rat rostral ventrolateral medulla in vitro. (24th Annual
Meeting of the Society for Neuroscience, Miami,
November 1994).
3. Hayar A, Feltz P. Réponses pré et
postsynaptic GABAergiques dans le noyau rostral ventrolatéral
bulbaire de rat in vitro. Societé des Neurosciences (France, Lyon, May 1995).
4. Hayar A, Piguet P, Poulter MO, Feltz P. Monophasic and
multiphasic GABA responses in neurons of the rat rostral ventrolateral
medulla in vitro. (25th Annual Meeting of the Society for Neuroscience,
San Diego, November 1995).
5. Hayar A, Piguet P, Feltz, P. Réponses
GABAergiques monophasiques et multiphasiques dans les neurones du noyau
rostral ventrolatéral bulbaire de rat in vitro. (63ème
Congrès de la Société de Physiologie, France, Strasbourg, December 1995).
6. Hayar A, Feltz P, Piguet P. Adrenergic responses
in silent and putative inhibitory pacemaker-like neurons of the rat
rostral ventrolateral medulla in vitro. (European Neuroscience Meeting,
France, Strasbourg, September 1996).
7. Hayar A, Piguet P, Schlichter R. Properties of
irregular firing neurons in the rostral ventrolateral medulla in vitro
and possible involvement in sympathoexcitatory function. (26th Annual
Meeting of the Society for Neuroscience, Washington
D.C., November 1996).
8. Hayar A, Guyenet P. Presynaptic effects mediated
by alpha2-adrenoceptors in the rat rostral ventrolateral medulla in
vitro. (28th Annual Meeting of the Society for Neuroscience, Los Angeles, November 1998).
9. Hayar A, Guyenet P. Tyramine releases predominantly
serotonin in the lower brainstem of neonate rats in vitro. (Washington
D.C., April 1999).
10. Hayar A, Guyenet P. Effect of tyramine and other
indirectly acting monoamines in the rostral ventrolateral medulla in
vitro. (29th Annual Meeting of the Society for Neuroscience, Miami, October 1999).
11. Hayar A, Shipley MT, Ennis M. Direct excitation
of mitral cells by activation of alpha1-adrenergic receptors in rat
olfactory bulb slices. (Sarasota,
April 2000).
12. Hayar A, Shipley MT, Ennis M. Norepinephrine excites
mitral cells by activation of alpha1-adrenergic receptors in rat
olfactory bulb slices. (30th Annual Meeting of the Society for
Neuroscience, New Orleans,
November 2000, Abstract).
13. Karnup SV, Hayar A, Ennis M, Shipley MT. Morphology
& Physiology of juxtaglomerular (JG) cells in rat main olfactory
bulb (MOB). (31st Annual Meeting of the Society for Neuroscience, San Diego, November 2001, Abstract).
14. Heinbockel T, Hayar A, Laaris N, Shipley MT, Ennis M.
Metabotropic glutamate receptors shape neuronal excitability and
synaptic responsiveness in mouse olfactory bulb slices. (31st Annual
Meeting of the Society for Neuroscience, San
Diego, November 2001, Abstract).
15. Aungst JL, Heyward P, Karnup SV, Hayar A, Shipley MT,
Puche AC. Robust inter-glomerular circuitry in the main olfactory
bulb. (32nd Annual Meeting of the Society for Neuroscience, Orlando, November 2002, Abstract).
16. Hayar A, Heinbockel T, Karnup S, Ennis M, Shipley MT.
Activation of metabotropic glutamate receptors enhances synaptic
interactions among juxtaglomerular neurons in olfactory bulb glomeruli.
(33rd Annual Meeting of the Society for Neuroscience, New Orleans, November 2003, Abstract).
17. Shipley MT, Karnup S, Ennis M, Hayar A. Olfactory
bulb external tufted cells provide monosynaptic excitatory input to
periglomerular (PG) and short axon (SA) cells. (33rd Annual Meeting of
the Society for Neuroscience, New Orleans,
November 2003, Abstract).
18. Hamilton KA, Heinbockel T, Hayar A, Szabo G, Erdelyi
F, Ennis M. Functional properties of interneurons in the external
plexiform layer of the olfactory bulb. (33rd Annual Meeting of the
Society for Neuroscience, New Orleans,
November 2003, Abstract).
19. Li C, Hayar A, Smith DV. Patch-clamp recording of
medullary taste neurons identified by retrograde labeling from the
pons. (33th Annual Meeting of the Society for Neuroscience, New Orleans, November 2003, Abstract).
20. Hayar A, Ennis M. Activation of metabotropic
glutamate receptors (mGluRs) enhances bursting in external tufted cells
of the olfactory bulb. (34th Annual Meeting of the Society for
Neuroscience, San Diego, October
2004, Abstract).
21. Hayar A, Shipley MT, Ennis M. The bursting of
olfactory bulb external tufted (ET) cells is coordinated by synaptic
and gap junction currents. (27th Annual Meeting of the Association for
Chemoreception
Sciences, Sarasota, April 2005, Abstract).
22. Hayar A, Ennis M. Activation of metabotropic
glutamate receptors (mGluRs) enhances bursting in external tufted cells
of the olfactory bulb. (27th Annual Meeting of the Association for
Chemoreception Sciences, Sarasota,
April 2005, Abstract).
23. Hamilton KA, Hayar A, Ennis M Spiking properties of
EPL interneurons. (27th Annual Meeting of the Association for
Chemoreception Sciences, Sarasota,
April 2005, Abstract).
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